Bounty for answer to chronic anus inflammation of beagle

My 14 year old beagle has been battling with an inflamed, swollen anus and strong itching. I've been running from vet to vet, spending hundreds but to no avail. If any of you is able to guide me in the right direction that leads to an answer or even better a cure I will reward them with a 150€ bounty or more through the payment method of their choice. A creme containing cortisone and dermamycine alleviates the itching but only temporarily and less and less each time. A combination shot of Duphamox and Chelidonium majus was very effective and greatly reduced the itching and swelling for about a week. However the swelling and itching came back. She's been on a high dose of Sucrabest for 2 weeks because one vet suspected inflammed intestines. She's been on metacam for 4 days with no visible changes. In fact the swelling and itching is increasing. She is extremely fit for her age, has great appetite and energy, no problems with digestion, normal stool. Her anal glands are normal. She really only has an inflamed, swollen, itching butthole. Today I've noticed groups of dark spots around her rectum. Also some white sacks sticking out. The swelling on her recting seems to originate from 3 spots. I will attach pics. https://photos.app.goo.gl/mhMsfHyzgnS4Vem58 https://photos.app.goo.gl/wGVKLFneAsmQkUMj7 https://photos.app.goo.gl/3NHpGcZBfBVtp4AaA I would greatly appreciate any ideas you guys can throw at me. I just want to help my baby and the local vets can't seem to.

Hello - I am unable to see the pictures at the moment, but you may be describing a typical skin disease vet-client mismatch in expectations here.   Sone diseases are acute, ie they happen and the animal is sick, the vet gives treatment and the problem resolves.  A typical example might be a wound, that is sutured and then heals.  However, the vast majority of skin complaints are not like this;  skin inflammation (and the anus is just very, very senaitive skin over muscle) tends to br chronic, ie, it depends what is causing it but in most cases, it recurrs.

So, in the same way that a dog with diabetes will need insulin on an ongoing basis, a dog with a skin inflammation involving the anal glands may need chronic or regular treatment.  Some other underlying causes may need to be addressed, for example pain in the area (leads to licking), constipation, allergy, yeast infection and so on.  I cannot see the picture of the dark spots at this moment in time - will check later on a proper computer - but dark spots can relate to anal gland discharge / yeast infection, but also to things like melanoma which is, of course, a different concern entirely.   We would reccommend going back to your vet and asking what may have caused the problem, as well as how to treat it.  Prepare yourself for the possibity that if your vet can't be sure, then further investigation or trial lifestyle changes may be needed.