Treatment for cutaneous melanoma

My dog is currently at stage 0-1 with a cutaneous melanoma, he’s had his second surgery to create bigger margins and his CT/lymphnodes are all clear, we were offered the Oncept vaccine but now we are told there is a supply issue and we may not be able to use it.  I have been offered the carboplatin injections or the palladia tablets, I was wondering if anyone had any experience with these? I have read a couple of studies and it’s scared me that a couple of dogs had to be euthanised due to severe gastrointestinal problems due to the carboplatin.  Any information would be greatly appreciated.

Hello - this site is usually used at the pre-vet or 'how to talk to my vet' level, but it sounds as though you're well past that; you have a diagnosis, have had a revision surgery for the borders and are now at the stage of choosing chemotherapy drugs, which I'm afraid I haven't used or even heard very much about.  I have used Masitinib.  However, I can give you some good questions for your vet or specialist;  How many times have you used each of these options?  What sort of side effects (if any) have you seen? Are research statistics supportive of using them?  What are the chances of the tumour returning with the work thats been done so far?  How will these drugs change that?  If this was your dog, which would you recommend and why?  A couple of dogs being euthanased due to severe GI effects sounds rather bad; I wonder whether there are steps that can be taken to reduce the likelihood of this?  It would also be important to me to establish whether, for example, this was 2 dogs out of 100 in the study (ie 2 %) or 2 out of 10 dogs (a much bigger risk at 20%) or 2 dogs in total, both of which were accidentally double-dosed, or indeed whether it's an urban rumour as some drug side effect stories are. If you have heard of examples eg in the paper, always take the information with you for your vet to have a look at.  Your vet should be able to talk to drug companies about any drugs that are licensed, or to specialists about their basis for drug that are not.  Furthermore, always ask them to put this information in the clinical notes, in order that you can refer back to it later.   I'm sorry not to be more helpful and will return if I find out any more.

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