Whitish discharge from penis during evacuation

Good afternoon everyone. Our cat is a 1-year-old British Shorthair, who has always been inappetent. When he was about 4 months old, we noticed that he was leaking a whitish fluid from his penis after going to the litter box, either to pee or poo. The 4 different vets who have examined him since then have not been able to solve the problem. Here are the results of the examinations carried out so far: - cytological examination (slide of collected fluid, 2024.10): cocci and rare extracellular bacilli; presence of keratinized epithelial cells; abundant mucoprotein residue; absence of spermatozoa. - urine examination (2024.11): negative, but ‘proteinuria with inactive sediment’ was reported - abdominal echo (2024.12) negative. - bacteriological exam from urethral swab (2025.01): high number of Stenotrophomonas maltophilia and Pasteurella multocida germs. With 2-month therapy of amoxicillin + clavulanic acid 250mg, 1/4 tablet per day, the frequency of episodes decreased to 1/3 of the evacuations. At the end of therapy, the situation returned as before. - Haematology (2025.03): Erythrocytes 13.79 (ref. 6.54 - 12.20 M/µL); Haematocrit 53.2 (ref. 30.3 - 52.3 %); Haemoglobin 17.5 (ref. 9.8 - 16.2 g/dL); RDW 30.3 (ref. 15.0 - 27.0 %). Leakage did not decrease after castration. Photos attached. Can anyone please help us? Thanks in advance.

[REWRITTEN DUE TO LOST FORMATTING IN THE FIRST POST] Good afternoon everyone. Our cat is a 1-year-old British Shorthair, who has always been inappetent. When he was about 4 months old, we noticed that he was leaking a whitish fluid from his penis after going to the litter box, either to pee or poo. The 4 different vets who have examined him since then have not been able to solve the problem. Here are the results of the examinations carried out so far:

• cytological examination (slide of collected fluid, 2024.10): cocci and rare extracellular bacilli; presence of keratinized epithelial cells; abundant mucoprotein residue; absence of spermatozoa.
• urine examination (2024.11): negative, but ‘proteinuria with inactive sediment’ was reported
• abdominal echo (2024.12) negative.
• bacteriological exam from urethral swab (2025.01): high number of Stenotrophomonas maltophilia and Pasteurella multocida germs. With 2-month therapy of amoxicillin + clavulanic acid 250mg, 1/4 tablet per day, the frequency of episodes decreased to 1/3 of the evacuations. At the end of therapy, the situation returned as before.
• Haematology (2025.03): Erythrocytes 13.79 (ref. 6.54 - 12.20 M/µL); Haematocrit 53.2 (ref. 30.3 - 52.3 %); Haemoglobin 17.5 (ref. 9.8 - 16.2 g/dL); RDW 30.3 (ref. 15.0 - 27.0 %).

Leakage did not decrease after castration. Photos attached. Can anyone please help us? Thanks in advance.

Hello and thank you for this interesting question.  Interesting because, while penis discharges are common in dogs, they are not reported so frequently in felines.  It sounds from your description as though the symptoms responded to an antibiotic, so bacteria may have been involved and a longer course might clear the symptom up (unless the temporary improvement was a coincidence) - however, my concern would still be:  why is it there?  Even if its a bacterial infection, thats not a place that cats commonly get random infections.  So my question would be whether it might just restart in any case after an antibiotic course; whether there's a lump or bump (cancer?), a bite wound, a foreign body, a bladder problem, viral infection  or even a prostate problem underlying it.   It sounds as though your vet is part-way through the process of ruling out possible causes; Id be asking them, what haven't they ruled out?   What possibilities are still on the list?  Were two external testes definitely removed at castration?  I wonder whether examination under a GA or even intubation / radiography might be the next step.  Alternatively, if your vet thinks it appropriate, they might ask to refer the case or speak to an expert in reproductive medicine.  Nobody wants their pet to be an 'interesting case' but if you get to the bottom of this one, please will you let us know? One thing that concerned me about for message was the mention of multiple different vets and I'd like to check that they all worked for the same establishment. . Its worth saying - even if its not relevant to you, this may be to other people - that with 'interesting cases,' it often pays to see the same vet, because vets have an order / plan for doing things and when they take over someone else's case, often want to 'start again,' repeating things, or there is potential to make assumptions about what has prev iously happened and omit things from the work up.   If a vet doesnt come up with the right answer straight away, often thats because its difficult and takes time and they need to take advice - not necessarily because they aren't good at their job.  After all, we know about 5 body systens of 5 main species and are not experts in everything.  If the case keeps being passed around, it could be that noone has picked it up as their responsibility.  Are you attending for rechecks?  If possible, I would choose the best communicator / most interested of the four vets and go back to them, and try to get a handle on a) what differentials (possible causes) need to be ruled out b) what the vet needs to find out and how (this could be tests or knowledge / other vets) c) what the next step is. I hope that something there helps.

Thank you for taking the time for such an in-depth reply. I have to point out that we have seen more than one vet also due to logistical reasons, but the current vet has been following our cat for almost six months now. She is a competent and passionate person, and we trust her. The fourth vet is the ultrasound technician who did the ultrasound of his abdomen and who herself took an interest in the case. If we look for ideas and opinions online, it is because we have now realized that this is an uncommon case: so thank you for confirming this, sometimes we feel guilty for not being able to cure our little friend. If we find out anything useful, we will update you. Thanks again Liz