Hello - I hope that's a shampoo that's proven to target Malassezia as prescribed by your vet, because if so and there is no improvement then yeast may be on the way to being ruled out as a differential - something to ask your vet about. There is a primary hyperpigmentation (too much pigment) syndrome in dogs, but it tends to be genetic and associated with Daschunds. Acquired causes (things that can develop or be caught) include:
- hormonal disease (such as Cushings or hypothyroidism - this doesn't look typical
- yeast infection (as above)
- worryingly, mast cell tumours and lymphoma (these would need a biopsy to identify them)
- ringworm (although I have never seen it present like this)
This sort of thing is difficult to diagnose just by looking, so your vet might wish to arrange tests.