Similar lesion on both dogs noses

I have 2 year old dogs and both developed lesions on their noses. The first dog, yellow lab mix started 1 week prior to the other and has been treated with 2 different regimens. First vet tried anti-fungal meds and cream but circular place on right side of bridge of nose became worse not better. Area is raised, bubbly, bleeds with use like playing with tennis ball, dry, crusty, tender. Yellow lab also has similar spot on lip as well. Vet switched to antibiotics and steroids, and still not getting better. Secod dog developed same kind of spot on same side of nose a week later. Raised, bumpy, bleeding, cracking. I’ve been putting a pet formulated cbd balm the last several days but cannot see a difference. Noses look better in the morning but by end of day more irritated and cracking.

Hello!  When I looked at the first picture, my initial differentials list would have included neoplasia (cancer), benign lumps, demodex and autoimmune diseases.  Even though two dogs have displayed similar symptoms, these may still be on both dogs' differentials (un-ruled out possibilities) lists.  However, given the circumstances, something recently acquired from the environment and / or something infectious may be more likely.  For example, fungal disease such as ringworm, insect bites, secondary infection (bacterial) or direct contact with irritating substances should be considered.  MTF

Your vet will have a list like this in their heads - better tailored to the specifics of your dogs - and most vets will start by ruling out either the simplest or most likely thing.  It sounds as though they have tried a treatment and it didn't work, so re-presenting the case for further tests or trial treatments may be necessary.  Since then, it seems that the other dog has come down with the same signs, which might provide some clues.  For example, Ringworm, one possible possibility, is infectious to other dogs and humans so if that remains on your vets' list, they might ask you to take precautions.  These might involve  keeping both dogs away from other dogs and anyone who may be immunocompromised, and wearing gloves to touch them until Ringworm has been ruled out.

We would reccommend another check-up with your vet as soon as possible.  You might want to let them know what has happened on the phone in case it is necessary to prioritise the case, or in case they do feel that Ringworm is a concern, in which case they might talk to you about prevention of spread.

@cboone  did you ever find out what it was? My puppy has the same thing. Along with a fever and swollen lymph nodes, lots of tests done, and er visit lastnight, fluids and antibiotics, still don’t know what’s causing this.   Please let me know!