Liz Buchanan BVSc MRCVS
Keymaster
Ah! thank you for spelling out this detail. Most of those possibilities still apply; some kind of inflammation- a flea-bite, nick from vegetation, foreign body such as a thorn, inflammatory reaction, allergy (although very looks localised / intense for an allergy), demodex. (not an interdigital cyst then). Histiocytoma, cancer, leishmaniasis, Ringworm, foreign body could all still apply. Trauma (e.g. a wound or hot liquid dropping on paw) or licking at an area of soreness (eg arthritis) are still distinctly possible, although the latter might normally look more diffuse. Your vet may want to do tests to distinguish between these and other possibilities. In some countries / areas, Alabama Rot may belong on the differentials list, so please check urgently with your local clinician whether this might apply to you.
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